Journal
RHEUMATOLOGY INTERNATIONAL
Volume 29, Issue 7, Pages 793-796Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-008-0771-9
Keywords
PTPN22; Rheumatoid arthritis; Polymorphism; RF; Anti-CCP
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Funding
- Hungarian Scientific Research Foundation OTKA [T 49589, T 73430]
- Hungarian Ministry of Health [ETT 497/2006]
- Peter Pazmany Program [RET-008/2005]
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The C1858T allele of the PTPN22 gene has been reported to confer risk for RA; but in some reports, the effect was restricted to RF- and/or anti-CCP-seropositive patients. Hungarian RA patients and matched controls were genotyped. The 1858T allele showed an increased prevalence in RA patients compared to controls. The 1858T allele represents a risk factor in the whole RA population (P = 0.001); an association was found both in RF-seropositive (P = 0.001) and anti-CCP-seropositive patients (P = 0.001), and in subjects with the combination of these factors (P = 0.002). In TT homozygotes, the estimated susceptibility to RA was more than double (OR = 5.04) of that seen in TC heterozygotes (OR = 1.89); the same gene dosage effect was observed in all seropositive RA subgroups. Our data show that the Hungarian RA patients belong to the populations in which the 1858T allele represents a susceptibility factor both in the RF- and/or anti-CCP-seropositive subjects, and the association exhibit a gene dosage dependency.
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