Journal
RHEUMATOLOGY INTERNATIONAL
Volume 28, Issue 11, Pages 1155-1159Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00296-008-0590-z
Keywords
Infliximab; renal function; gastrointestinal amyloidosis; AA amyloidosis; rheumatoid arthritis
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We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA.
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