Journal
ONCOTARGET
Volume 6, Issue 23, Pages 19514-19527Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.4004
Keywords
cancer; exosome-like nanovesicles; Citrus limon L.; TRAIL-mediated cell death
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- University of Palermo
- FFR
- National Operational Programme for Research and Competitiveness [2007-2013-PON01_01059]
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Nanosized vesicles are considered key players in cell to cell communication, thus influencing physiological and pathological processes, including cancer. Nanovesicles have also been found in edible-plants and have shown therapeutic activity in inflammatory bowel diseases; however information on their role in affecting cancer progression is missing. Our study identify for the first time a fraction of vesicles from lemon juice (Citrus limon L.), obtained as a result of different ultracentrifugation, with density ranging from 1,15 to 1,19 g/ml and specific proteomic profile. By using an in vitro approach, we show that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL- mediated apoptotic cell death. Furthermore, we demonstrate that lemon nanovesicles suppress CML tumor growth in vivo by specifically reaching tumor site and by activating TRAIL-mediated apoptotic cell processes. Overall, this study suggests the possible use of plant-edible nanovesicles as a feasible approach in cancer treatment.
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