Journal
RHEUMATOLOGY
Volume 53, Issue 11, Pages 1940-1950Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/keu195
Keywords
anti-citrullinated protein/peptide antibodies; rheumatoid factor; autoimmunity; infection; interstitial lung disease; bronchiectasis; cigarette smoking; rheumatoid arthritis; pathogenesis
Categories
Funding
- Arthritis Research UK [19894]
- Centre for Investigation of Musculoskeletal Aging (CIMA)
- Alberta Innovates-Health Solutions
- Versus Arthritis [19894] Funding Source: researchfish
Ask authors/readers for more resources
Recent findings have highlighted the potential initiation of ACPA in sites away from the joint. Periodontitis is an example of this concept. This process in the gums appears to be independent of smoking, the main environmental risk factor for ACPA-positive RA. There is extensive literature regarding the potential role of smoking in the pathogenesis of ACPA-positive RA. As a consequence of this strong association, the lung has become the focus of research to determine whether processes within the lung are linked to the generation of ACPA. Here we outline the current body of evidence and explore the hypothesis that the lung as an organ of immune defence has a role in the pathogenesis of the autoimmune disease ACPA-positive RA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available