Journal
RHEUMATOLOGY
Volume 50, Issue 8, Pages 1466-1472Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/ker087
Keywords
Ankylosing spondylitis; Undifferentiated spondyloarthropathy; Ankylosing spondylitis disease activity scores; Magnetic resonance imaging; Tumour necrosis factor-alpha inhibitor
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Funding
- Ministry of Public Health of China
- Foundation of Guangdong province of China [2005A30801005]
- 5010 Subject of Sun Yat-Sen University
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Methods. Two hundred and thirty patients were included in our study. They consisted of patients with active AS (n = 87) and uSpA (n = 30) participating in a double-blind placebo-controlled randomized clinical trial of etanercept and patients with active AS (n = 58) and uSpA (n = 55) treated with infliximab. The disease activity and treatment effects were assessed by ASDAS, BASDAI, patient global and the acute inflammation score of lumbar and SI joints by MRI. Discriminatory ability of all the measures was analysed by standardized mean difference and t-score. Results. In both the AS and uSpA groups, ASDAS correlated well with patient global score (AS group: r = 0.65-0.72; uSpA group: r = 0.52-0.62), ESR (AS group: r = 0.57-0.81; uSpA group: r = 0.63-0.85) and CRP (AS group: r = 0.51-0.70; uSpA group: r = 0.61-0.76) both at baseline and in changes from baseline to 6 weeks after TNF-alpha inhibitor treatment. The ASDAS scores outperformed BASDAI, patient global score, ESR, CRP and the acute inflammation score by MRI in differentiating patients with different levels of disease activity and patients with different levels of change in both AS and uSpA groups. There was little difference in performance between the two versions of the ASDAS. Conclusion. The new ASDAS is a highly effective measure in assessing disease activity and a great discriminatory measurement to assess the efficacy of TNF-alpha inhibitor in Chinese AS patients and uSpA patients.
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