Journal
RHEUMATOLOGY
Volume 48, Issue 12, Pages 1524-1529Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/kep282
Keywords
Vasculitis; Henoch-Schonlein syndrome; Stroke; Posterior reversible encephalopathy syndrome; Peripheral neuropathy
Categories
Funding
- Swiss Society of Hypertension AstraZeneca Scholarship
Ask authors/readers for more resources
Objective. CNS or peripheral nervous system dysfunction sometimes occurs in Henoch-Schonlein patients. Methods. We review all Henoch-Schonlein cases published after 1969 with CNS dysfunction without severe hypertension and neuroimaging studies (n=35), cranial or peripheral neuropathy (n=15), both CNS and peripheral nervous system dysfunction without severe hypertension (n=2) or nervous system dysfunction with severe hypertension (n=2). Forty-four of the 54 patients were <20 years of age. Results. In patients with CNS dysfunction without or with severe hypertension the following presentations were observed in decreasing order of frequency: altered level of consciousness, convulsions, focal neurological deficits, visual abnormalities and verbal disability. Imaging studies disclosed the following lesions: vascular lesions almost always involving two or more vessels, intracerebral haemorrhage, posterior subcortical oedema, diffuse brain oedema and thrombosis of the superior sagittal sinus. Following lesions were noted in the subjects with cranial or peripheral neuropathy without severe hypertension: peroneal neuropathy, peripheral facial palsy, Guillain-Barre syndrome, brachial plexopathy, posterior tibial nerve neuropathy, femoral neuropathy, ulnar neuropathy and mononeuritis multiplex. Persisting signs of either CNS (n=9) or peripheral (n=1) nervous system dysfunction were sometimes reported. Conclusions. In Henoch-Schonlein syndrome, signs of nervous system dysfunction are uncommon but clinically relevant. This review helps clinicians managing Henoch-Schonlein syndrome with nervous system dysfunction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available