Journal
RHEUMATOLOGY
Volume 47, Issue 7, Pages 1077-1081Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/ken128
Keywords
primary care; knee pain; osteoarthritis; health economics; non-steroidal anti-inflammatory drugs; topical non-steroidal anti-inflammatory drugs
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Funding
- MRC [MC_U122785831] Funding Source: UKRI
- Medical Research Council [MC_U122785831] Funding Source: researchfish
- National Institute for Health Research [01/09/02] Funding Source: researchfish
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Objective. Advice to use topical or oral NSAIDs is equally effective for the treatment of knee pain in older people. The ingredient cost of topical preparations is typically more than oral preparations, but could save costs because they have fewer adverse effects. A costutility study is needed to decide on their comparative cost effectiveness. Methods. We recruited 585 people aged >= 50 yrs with knee pain; 282 participated in a randomized controlled trial and 303 in a patient preference study from 26 MRC General Practice Research Framework practices in the UK. They received advice to preferentially use topical or oral NSAIDs for knee pain. We calculated the comparative cost per quality-adjusted life year (QALY) from both a National Health Service (NHS) and a societal perspective over 12 and 24 months. Results. Compared with the topical route, oral NSAIDs cost the NHS 191 pound and 72 pound more over 1 yr in the randomized trial and preference study, respectively. The cost per QALY, from an NHS perspective, was in the range of 9000- pound 12000 pound in the randomized trial. In the preference study, it was 2564 pound over 1 yr, but over 2 yrs the oral route was dominant. Conclusions. Our costeffectiveness analysis supports the use of oral NSAIDs in selected patients. Nevertheless, deciding to recommend oral NSAIDs in preference to topical NSAIDs could have a substantial impact on NHS costs because of the uncertainty in the costeffectiveness estimate.
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