Journal
RHEUMATOLOGY
Volume 47, Issue 9, Pages 1286-1298Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rheumatology/ken159
Keywords
systematic review; rheumatoid arthritis; cardiovascular; hypertension; inflammation; physical inactivity; medication; non-steroidal anti-inflammatory drugs; recommendations; glucocorticosteroids
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Funding
- Empirikion Institute, Athens, Greece
- Arthritis Research Campaign (ARC) [17883]
- Arthritis Research Campaign [17682]
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RA associates with an increased burden of cardiovascular disease, which is at least partially attributed to classical risk factors such as hypertension (HT) and dyslipidaemia. HT is highly prevalent, and seems to be under-diagnosed and under-treated among patients with RA. In this review, we discuss the mechanisms that may lead to increased blood pressure in such patients, paying particular attention to commonly used drugs for the treatment of RA. We also suggest screening strategies and management algorithms for HT, specific to the RA population, although it is clear that these need to be formally assessed in prospective randomized controlled trials designed specifically for the purpose, which, unfortunately, are currently lacking.
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