Journal
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
Volume 40, Issue 4, Pages 735-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2014.07.015
Keywords
Immune tolerance; Regulatory T cells; pMHC tetramers; Rheumatoid arthritis; Type 1 diabetes; HLA susceptibility
Categories
Funding
- Arthritis Queensland
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Despite treatment advances, rheumatoid arthritis (RA) is still associated with significant disability, decreased work capacity, and reduced life expectancy. Effective immunotherapies to restore immune tolerance promise greater specificity, lower toxicity, and a longer-term solution to controlling and preventing RA. Design of effective therapies requires a fundamental understanding of the critical immunopathogenetic pathways in RA. This article reviews advances in the understanding of self-antigen-specific T cells in autoimmune diseases including RA and type 1 diabetes, which bring exciting insights to the mechanisms underpinning loss of tolerance and how tolerance could be restored for disease prevention in the preclinical or recent-onset period.
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