Journal
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
Volume 36, Issue 2, Pages 311-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.rdc.2010.02.004
Keywords
Synovial fibroblasts; T lymphocytes; B lymphocytes; Antigen-presenting cells; Endothelial cells; Cytokines
Categories
Funding
- NIH [RO-1 AR38477]
- American College of Rheumatology Research and Education Foundation
- Immunology Training Grant and Rackham Pre-doctoral Merit Fellowship
- Arthritis Foundation Arthritis Investigator Award
- NIH K Award
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Understanding the pathogenesis of joint inflammation and destruction in rheumatoid arthritis involves dissection of the cellular and molecular interactions that occur in synovial tissue. Development of effective targeted therapies has been based on progress in achieving such insights. Safer and more specific approaches to treatment could flow from discovery of cell-cell interaction pathways that are specific to inflammation of the joint and less important in the defense against systemic infection. This article highlights selected cell-cell interactions in rheumatoid arthritis synovium that may be worthy of evaluation as future therapeutic targets.
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