Journal
ONCOTARGET
Volume 6, Issue 37, Pages 40186-40201Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.5529
Keywords
RNAseq; oral squamous cell carcinoma; OSCC; dysplasia; non-coding
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Funding
- Yorkshire Cancer Research [L341PG]
- Wellcome Trust
- University of Leeds [RGCALA101195]
- Betty Woolsey endowment
- Cancer Research UK Leeds Centre
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Oral squamous cell carcinoma (OSCC) is a prevalent cancer with poor prognosis. Most OSCC progresses via a non-malignant stage called dysplasia. Effective treatment of dysplasia prior to potential malignant transformation is an unmet clinical need. To identify markers of early disease, we performed RNA sequencing of 19 matched HPV negative patient trios: normal oral mucosa, dysplasia and associated OSCC. We performed differential gene expression, principal component and correlated gene network analysis using these data. We found differences in the immune cell signatures present at different disease stages and were able to distinguish early events in pathogenesis, such as upregulation of many HOX genes, from later events, such as down-regulation of adherens junctions. We herein highlight novel coding and non-coding candidates for involvement in oral dysplasia development and malignant transformation, and speculate on how our findings may guide further translational research into the treatment of oral dysplasia.
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