Journal
REVUE NEUROLOGIQUE
Volume 165, Issue 12, Pages 1023-1028Publisher
MASSON EDITEUR
DOI: 10.1016/j.neurol.2009.09.012
Keywords
Microglia; Macrophages; Multiple sclerosis; Neuroinflammation; Neurodegeneration
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Funding
- Association pour la recherche Sur la sclerose en plaques (ARSEP) or Society for Research on Multiple Sclerosis)
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Diffuse neurodegeneration is now considered to be the main cause of irreversible neurological disability in multiple sclerosis (MS). Demonstration of a diffuse inflammatory reaction in the MS brain led to the assumption that diffuse neuroinflammation induces diffuse neurodegeneration. Macrophages/microglia accumulate throughout the MS brain and are, therefore, considered the main culprits implicated in the development of neurodegeneration. However, recent advances in the understanding of macrophage/microglia functions and origins have now challenged that view. This report is a summary of these advances, and discusses their contribution to the perception of macrophage/microglia functions in MS-associated neurodegeneration. (C) 2009 Elsevier Masson SAS. All rights reserved.
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