Journal
ONCOTARGET
Volume 6, Issue 11, Pages 9542-9550Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.3283
Keywords
soft tissue sarcoma; metastasis; immunity; prognosis
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Metastatic soft tissue sarcomas (STS) represent enormous challenges to improve the low survival rate, which is almost the same as past 2 decades ago. Prognosis of cancer patients are based not only on tumor-related factors but also on host-related factors, particularly systemic inflammatory response. We evaluated the association among possible risk factors and survival for metastatic STS by reviewed a single-institution nearly 50-year experience. We found that both monocyte ratio and NLR ratio were significant prognostic predictors for OS and PFS of metastatic STS. And patients with monocyte ratio or NLR ratio > 1 should be screened out as candidates for more intensive or aggressive multimodality treatments and more aggressive followup. For this reason, this result could serve as a basis for future prospective study.
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