Journal
ONCOTARGET
Volume 6, Issue 32, Pages 32575-32585Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.5331
Keywords
EMMPRIN; bone marrow-derived cells; SDF-1; VEGF; tumor growth and metastasis
Categories
Funding
- National Natural Science Foundation of China [81101744]
- Yale Center for Clinical Investigation [CTSA UL1 TR000142]
- Matthew Larson Foundation
- Chinese Scholarship Council
Ask authors/readers for more resources
EMMPRIN, a cell adhesion molecule highly expressed in a variety of tumors, is associated with poor prognosis in cancer patients. Mechanistically, EMMPRIN has been characterized to contribute to tumor development and progression by controlling the expression of MMPs and VEGF. In the present study, by using fluorescently labeled bone marrow-derived cells (BMDCs), we found that the down-regulation of EMMPRIN expression in cancer cells reduces tumor growth and metastasis, and is associated with the reduced recruitment of BMDCs. Further protein profiling studies suggest that EMMPRIN controls BMDC recruitment through regulating the secretion of soluble factors, notably, VEGF and SDF-1. We demonstrate that the expression and secretion of SDF-1 in tumor cells are regulated by EMMPRIN. This study reveals a novel mechanism by which EMMPRIN promotes tumor growth and metastasis by recruitment of BMDCs through controlling secretion and paracrine signaling of SDF-1 and VEGF.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available