Journal
REVISTA MEDICA DE CHILE
Volume 141, Issue 7, Pages 895-902Publisher
SOC MEDICA SANTIAGO
DOI: 10.4067/S0034-98872013000700009
Keywords
Pre-eclampsia; Purines; Uric acid
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Funding
- NICHD NIH HHS [NIH P01 HD30367] Funding Source: Medline
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Uric acid is the final metabolite of purine break down, such as ATP, ADP, AMP, adenosine, inosine and hypoxanthine. The metabolite has been used broadly as a renal failure marker, as well as a risk factor for maternal and neonatal morbidity during pre-eclamptic pregnancies. High purine levels are observed in pre-eclamptic pregnancies, but the sources of these purines are unknown. However, there is evidence that pre-eclampsia (mainly severe pre-eclampsia) is associated with an increased release of cellular fragments (or micropartides) from the placenta to the maternal circulation. These in fact could be the substrate for purine metabolism. Considering this background, we propose that purines and uric acid are part of the same physiopathological phenomenon in pre-eclampsia (i.e., placental dysfunction) and could become biomarkers for placental dysfunction and postnatal adverse events.
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