Journal
ONCOTARGET
Volume 6, Issue 16, Pages 13914-13924Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.4227
Keywords
microRNA; gallbladder cancer; proliferation; apoptosis; metastasis
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81401847, 81272053, 81330044]
- Ministry of Education of China [20131106110004]
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Gallbladder cancer is the most common biliary tract malignancy with poor prognosis. MicroRNAs (miRNAs) are a class of small, endogenous, non-coding RNAs of 19-23 nucleotides in length, which regulate gene expression at post-transcriptional and translational levels. Several studies have demonstrated aberrant expression of miRNAs in gallbladder cancer tissues. Recent evidences also demonstrated that specific miRNAs are functionally involved in gallbladder cancer development through modulating cell proliferation, apoptosis, migration, invasion and metastasis. In this review, we explore the possibilities of using miRNAs as prognostic, diagnostic markers and therapeutic targets in gallbladder cancer.
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