Journal
ONCOTARGET
Volume 6, Issue 31, Pages 30545-30556Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.5906
Keywords
Lactobacillus; immunology; elderly; nuclear magnetic resonance; Gerotarget
Categories
Funding
- Estonian Science Foundation [6782]
- Ministry of Higher Education and Research [SF018255]
- European Community's Regional Development Fund of the Competence Centre Program of the Enterprise Estonia of the Bio-Competence Centre of Healthy Dairy Products LLC [EU30002]
- Research Endorsement Trust Fund of the University of Reading
- Royal Society [RG120388]
- Medical Research Council [M004945/1]
- European Union [613979]
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We aimed at evaluating the association between intestinal Lactobacillus sp. composition and their metabolic activity with the host metabolism in adult and elderly individuals. Faecal and plasma metabolites were measured and correlated to the Lactobacillus species distribution in healthy Estonian cohorts of adult (n = 16; < 48 y) and elderly (n = 33; > 65 y). Total cholesterol, LDL, C-reactive protein and glycated hemoglobin were statistically higher in elderly, while platelets, white blood cells and urinary creatinine were higher in adults. Aging was associated with the presence of L. paracasei and L. plantarum and the absence of L. salivarius and L. helveticus. High levels of intestinal Lactobacillus sp. were positively associated with increased concentrations of faecal short chain fatty acids, lactate and essential amino acids. In adults, high red blood cell distribution width was positively associated with presence of L. helveticus and absence of L. ruminis. L. helveticus was correlated to lactate and butyrate in faecal waters. This indicates a strong relationship between the composition of the gut Lactobacillus sp. and host metabolism. Our results confirm that aging is associated with modulations of blood biomarkers and intestinal Lactobacillus species composition. We identified specific Lactobacillus contributions to gut metabolic environment and related those to blood biomarkers. Such associations may prove useful to decipher the biological mechanisms underlying host-gut microbial metabolic interactions in an ageing population.
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