Journal
ONCOTARGET
Volume 6, Issue 42, Pages 44191-44206Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6176
Keywords
cancer; cancer stem cell; anti-cancer treatment; cancer stem cell marker; cancer stem cell model
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Funding
- Indo-Australia Science and Technology Fund [ST040007]
- Victorian Cancer Agency Platform Technology Capacity Building Grant [PTCP-02]
- CASS Foundation (Australia)
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Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.
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