Journal
REVISTA BRASILEIRA DE PSIQUIATRIA
Volume 35, Issue -, Pages S82-S91Publisher
ASSOC BRASILEIRA PSIQUIATRIA
DOI: 10.1590/1516-4446-2013-1157
Keywords
Neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease; animal models
Categories
Funding
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [APQ-00487-11]
- Programa de Apoio aos Ntkleos de Excelencia (PRONEX) FAPEMIG [CEX-APQ-04219-10]
- Conselho Nacional de Desenvolvinnento Cientifico e TecnolOgico (CNPq) [309811/2010-4]
- FAPEMIG [APQ-04625-10, PPM-00567-11]
- CNPq [402853/2012-1, 474748/2012-0]
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The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able to preclude their emergence or at least slow their progression. Animal models contribute to increase the knowledge on the pathophysiology of neurodegenerative diseases. These models reproduce different aspects of a given disease, as well as the histopathological lesions and its main symptoms. The purpose of this review is to present the main animal models for AD, PD, and Huntington's disease.
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