Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 22, Issue 1, Pages 29-35Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.2921
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Funding
- Singapore Agency for Science, Technology, and Research (A*STAR)
- A.P. Giannini Foundation
- US National Institutes of Health
- Early Career Scientist of the Howard Hughes Medical Institute
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Thousands of long noncoding RNAs (IncRNAs) have been discovered, but their functional characterization has been slowed by a limited set of research tools. Here we review emerging RNA-centric methods to interrogate the intrinsic structure of IncRNAs as well as their genomic localization and biochemical partners. Understanding these technologies, including their advantages and caveats, and developing them in the future will be essential to progress from description to comprehension of the myriad roles of IncRNAs.
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