Chemical composition, antischistosomal and cytotoxic effects of the essential oil of Lavandula angustifolia grown in Southeastern Brazil

This paper reports on the chemical composition, the in vitro antischistosomal effects, and the,cytotoxicity of the essential Oil from the leaves of Lavandula angustifolia Mill.; Lamiaceae, grown in the Southeastern Brazil. Bornel (22:4%), epi-alpha-muurolol (13.4%), alpha-,bisabolol (13.1%), precocene I (13.0%), and eucalyptol (7.9%) were the major essential oil constituents. Incubation With essential oil-at 200 mu g/ml killed all the adult S. mansoni worms after 24h (LC50 117.7. arid-103.9 mu g/ml at 24 and 120 h of incubation, respectively): At a concentration of 50 mu g/ the essential oil significantly decreased the motor activity and reduced the percentage of egg development after 110 h In addition, the essential oil,Separated all the coupled S. mansoni worm pairs into individual male and female-at 25 and 50 mu g/ml within 120 and 24 respectively. this oil was cytotoxic to GMO7492-A cells at only Concentrations higher than 200 mu g/ml (IC(50)243.7 mu g/ml). These data indicate that LA-EO exhibits moderate in vitro activity against adult S. rnansoni and exerts remarkable effects on eggs development. (C) 2013 Brazilian Society of Pharmacognosy. Published by Elsevier Editora Ltda. All rights reserved.