Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 22, Issue 11, Pages 853-858Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3078
Keywords
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Funding
- German Federal Ministry of Education and Research (BMBF) [01ZXI302]
- German CellNetworks Cluster of Excellence [EXC81]
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Long noncoding telomeric repeat-containing RNA (TERRA) has been implicated in telomere maintenance in a telomerase-dependent and a telomerase-independent manner during replicative senescence and cancer. TERRA's proposed activities are diverse, thus making it difficult to pinpoint the critical roles that TERRA may have. We propose that TERRA orchestrates different activities at chromosome ends in a manner that depends on the state of the telomere.
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