Journal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
Volume 20, Issue 6, Pages 933-938Publisher
SOC BRASILEIRA FARMACOGNOSIA
DOI: 10.1590/S0102-695X2010005000043
Keywords
anti-inflammatory; antinociceptive; Sideroxylon obtusifolium; Sapotaceae
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- Fundacao de Apoio a Pesquisa e a Inovacao Tecnologica do Estado de Sergipe (PIBIC)
- Universidade Federal de Sergipe
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Sideroxylon obtusifolium (Humb. ex Roem. & Schult.) T. D. Penn., Sapotaceae, is a plant with analgesic and anti-inflammatory activities used in folk medicine. In order to evaluate the actions of this plant, studies were performed on antinociceptive and anti-inflammatory activities with the ethanol extract (EE) of inner bark (100-400 mg/kg). Oral treatment with the EE elicited inhibitory activity (200 and 400 mg/kg, p<0.01) on acetic acid effect and reduced (100, 200, and 400 mg/kg, p<0.001) the formalin effect at the second-phase, however it did not elicit any inhibitory effect on hot-plate test. Carrageenan-induced oedema formation and leukocyte migration into the peritoneal cavity were reduced with the EE at 100, 200, and 400 mg/kg (p<0.001). In conclusion, the EE of Sideroxylon obtusifolium shows antinociceptive and anti-inflammatory activities, supporting the folkloric usage of the plant to treat pain and various inflammatory diseases.
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