Journal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
Volume 18, Issue 4, Pages 544-548Publisher
SOC BRASILEIRA FARMACOGNOSIA
DOI: 10.1590/S0102-695X2008000400008
Keywords
Arrabidaea chica; Bignoniaceae; flavonoids; Trichophyton mentagrophytes; antifungal activity; Trypanosoma cruzi; trypanocidal effect
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Dr. Alaide Braga de Oliveira - UFMG
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Arrabidaea chica (HBK.) Verlot (Bignoniaceae). vernacular name Pariri, is a climbing shrub, widespread from South Mexico to Guyana and central Brazil and is traditionally indicated to treat symptoms of inflammations and skin affections. Its ethanol extract was chemically investigated and tested,against yeasts and dermatophytic fungi. The trypanocidal activity of the same extract was also evaluated. This work reports the isolation of three flavonoids, the total growth inhibition of Trichophyton mentagrophytes and a significant trypanocidal effect of the ethanol extract and its fractions. No relevant acute toxicity was detected even at a dose of 1000 mg/kg.
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