Journal
REVIEWS IN THE NEUROSCIENCES
Volume 30, Issue 3, Pages 279-287Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/revneuro-2018-0004
Keywords
apoptosis; cell death; mitochondria; neurological diseases; targeted treatment
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Funding
- National Key Research Project [2017YFA0104200]
- National Natural Science Foundation of China [81330016, 81630038, 81771634]
- Science and Technology Project of Sichuan Province [2016TD0002]
- National Key Project of Neonatal Children [1311200003303]
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Omi/HtrA2 is a serine protease present in the mitochondrial space. When stimulated by external signals, HtrA2 is released into the mitochondria] matrix where it regulates cell death through its interaction with apoptotic and autophagic signaling pathways. Omi/HtrA2 is closely related to the pathogenesis of neurological diseases, such as neurodegeneration and hypoxic ischemic brain damage. Here, we summarize the biological characteristics of Omi/HtrA2 and its role in neurological diseases, which will provide new hints in developing Omi/HtrA2 as a therapeutic target for neurological diseases.
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