Journal
REVIEWS IN THE NEUROSCIENCES
Volume 24, Issue 3, Pages 267-278Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/revneuro-2013-0004
Keywords
acetylcholine; cognition; cognitive deficits; executive function; frontal cortex; Parkinson's disease
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Funding
- NINDS NIH HHS [K08 NS078100] Funding Source: Medline
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Cognitive dysfunction is a common symptom of Parkinson's disease (PD) that causes significant morbidity and mortality. The severity of these symptoms ranges from minor executive symptoms to frank dementia involving multiple domains. In the present review, we will concentrate on the aspects of cognitive impairment associated with prefrontal dopaminergic dysfunction, seen in non-demented patients with PD. These symptoms include executive dysfunction and disorders of thought, such as hallucinations and psychosis. Such symptoms may go on to predict dementia related to PD, which involves amnestic dysfunction and is typically seen later in the disease. Cognitive symptoms are associated with dysfunction in cholinergic circuits, in addition to the abnormalities in the prefrontal dopaminergic system. These circuits can be carefully studied and evaluated in PD, and could be lever-aged to treat difficult clinical problems related to cognitive symptoms of PD.
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