4.5 Review

Virological and immunological mechanisms in the pathogenesis of human T-cell leukemia virus type 1

Journal

REVIEWS IN MEDICAL VIROLOGY
Volume 23, Issue 5, Pages 269-280

Publisher

WILEY
DOI: 10.1002/rmv.1745

Keywords

-

Categories

Funding

  1. Ministry of Education, Science, Sports and Culture of Japan
  2. Japanese Leukemia Foundation and Leuka
  3. Grants-in-Aid for Scientific Research [22114003] Funding Source: KAKEN

Ask authors/readers for more resources

Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus shown to cause human disease, such as adult T-cell leukemia and HTLV-1 associated myelopathy/tropic spastic paraparesis. HTLV-1 mainly infects CD4 T cells and deregulates their differentiation, function and homeostasis, which should contribute to the pathogenesis of HTLV-1, for example, inducing transformation of infected CD4 T cells and chronic inflammatory diseases. Therefore, not only virological approach but also immunological approach regarding CD4 T cells are required to understand how HTLV-1 causes related human diseases. This review focuses on recent advances in our understanding of the interaction between HTLV-1 and the main host cell, CD4 T cells, which should provide us some clue to the mechanisms of HTLV-1 mediated pathogenesis. Copyright (c) 2013 John Wiley & Sons, Ltd.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available