Journal
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
Volume 11, Issue 1, Pages 31-39Publisher
SPRINGER
DOI: 10.1007/s11154-010-9131-7
Keywords
Diabetic cardiomyopathy; Diastolic dysfunction; Substrate utilization; Mitochondrial dysfunction; Uncoupling
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Funding
- NHLBI NIH HHS [U01 HL087947, P30 HL101310, P30 HL101310-01, U01 HL087947-04] Funding Source: Medline
- NIDDK NIH HHS [R01 DK092065] Funding Source: Medline
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Diabetes is associated with increased incidence of heart failure even after controlling for coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become an increasingly recognized entity among clinicians, a better understanding of its pathophysiology is necessary for early diagnosis and the development of treatment strategies for diabetes-associated cardiovascular dysfunction. We will review recent basic and clinical research into the manifestations and the pathophysiological mechanisms of diabetic cardiomyopathy. The discussion will be focused on the structural, functional and metabolic changes that occur in the myocardium in diabetes and how these changes may contribute to the development of diabetic cardiomyopathy in affected humans and relevant animal models.
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