Journal
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
Volume 11, Issue 1, Pages 61-74Publisher
SPRINGER
DOI: 10.1007/s11154-010-9134-4
Keywords
Endothelium; Nitric oxide; Inflammation; Diabetes mellitus; Mitochondria; Protein kinase C
Categories
Funding
- NIH- sponsored Boston University Medical Center Leadership Program in Vascular Medicine [K12 HL083781]
- NIH [HL083801, HL081587, HL083269, HL75795]
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Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. This article reviews the evidence linking endothelial dysfunction to human diabetes mellitus and experimental studies that investigated the responsible mechanisms. We then discuss the implications of these studies for current management and for new approaches for the prevention and treatment of cardiovascular disease in patients with diabetes mellitus.
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