Journal
RETROVIROLOGY
Volume 11, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12977-014-0079-7
Keywords
HIV-1 subtype; Protease; Protease inhibitor; Gag amino acid substitution; Drug resistance
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Funding
- AIDS Reference Laboratory of Leuven
- Belgian Ministry of Social Affairs through a fund within the Health Insurance System
- Fonds voor Wetenschappelijk Onderzoek-Flanders (FWO) [PDO/11, G.0692.14]
- European Community's Seventh Framework Programme (FP7/2007-2013) under the project Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN) [223131]
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HIV-1 Gag amino acid substitutions associated with protease inhibitor (PI) treatment have mainly been reported in subtype B, while information on other subtypes is scarce. Using sequences from 11613 patients infected with different HIV-1 subtypes, we evaluated the prevalence of 93 Gag amino acid substitutions and their association with genotypic PI resistance. A significant association was found for 13 Gag substitutions, including A431V in both subtype B and CRF01_AE. K415R in subtype C and S451G in subtype B were newly identified. Most PI-associated Gag substitutions are located in the flexible C-terminal domain, revealing the key role this region plays in PI resistance.
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