Journal
RETROVIROLOGY
Volume 11, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12977-014-0069-9
Keywords
HIV-1; T cell; Multiple infection; Recombination; Immunodominance; Acute infection
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Funding
- Center for HIV-AIDS Vaccine Immunology (NIAID) [AI067854]
- Duke University Center for AIDS Research (CFAR), an NIH funded program [5P30 AI064518]
- MRC [MR/K012037/1] Funding Source: UKRI
- Medical Research Council [MR/K012037/1] Funding Source: researchfish
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Background: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Results: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. Conclusions: Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.
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