Journal
RETROVIROLOGY
Volume 9, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1742-4690-9-112
Keywords
-
Categories
Funding
- Ministry of Education, Science, Technology, Sports and Culture of Japan [22590428]
- Ministry of Health, Labor, and Welfare of Japan [H24-005, -008]
- NIAID, NIH
- Office of the Director, NIH
- Bill and Melinda Gates Foundation
- NIH [AI063944, AI080225]
- Grants-in-Aid for Scientific Research [22590428] Funding Source: KAKEN
Ask authors/readers for more resources
Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-host interactions. Among retroviruses, the primate lentiviruses have one of the more complex genome structures with three categories of viral genes: structural, regulatory, and accessory genes. Over time, we have gained increasing understanding of the lentivirus life cycle from studying host factors that support virus replication. Similarly, studies on host restriction factors that inhibit viral replication have also made significant contributions to our knowledge. Here, we review recent progress on the rapidly growing field of restriction factors, focusing on the antiretroviral activities of APOBEC3G, TRIM5, tetherin, SAMHD1, MOV10, and cellular microRNAs (miRNAs), and the counter-activities of Vif, Vpu, Vpr, Vpx, and Nef.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available