Journal
RETROVIROLOGY
Volume 5, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1742-4690-5-76
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Funding
- Sixth Research Framework Programme of the European Union [INCA LSHC-CT-2005-018704]
- Belgian Foundation against Cancer
- Bekales Foundation
- Fonds National de la Recherche Scientifique (FRS-FNRS and Televie)
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The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
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