Journal
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Volume 32, Issue 4, Pages 826-833Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0b013e3182215ae9
Keywords
cystoid macular edema; choroideremia; carbonic anhydrase inhibitor; spectral-domain OCT
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Funding
- Foundation Fighting Blindness, Owings Mills, MD
- Grant Healthcare Foundation, Lake Forest, IL
- National Institutes of Health [EY019510, EYO1792]
- Research to Prevent Blindness
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Purpose: To determine the value of a topical carbonic anhydrase inhibitor on the macular thickness and function in choroideremia patients with cystoid macular edema. Methods: Two choroideremia patients with cystoid macular edema, observed by spectral-domain optical coherence tomography, were treated with a topical form of carbonic anhydrase inhibitor. Examinations performed before and during treatment included best-corrected visual acuity by using the Early Treatment Diabetic Retinopathy Study charts and contrast sensitivity measured with briefly presented grating targets and the Pelli-Robson letter contrast sensitivity chart, microperimetry, and spectral-domain optical coherence tomography. Results: The 2 choroideremia patients treated with dorzolamide 2% formulation had a noticeable reduction in macular thickness by spectral-domain optical coherence tomography. This reduction was found in both eyes after 2 months of treatment. After an additional 3 months of the same treatment regimen, a more noticeable reduction in macular thickness was observed. The two study patients had improvement of their visual acuity, in at least one eye, on Early Treatment Diabetic Retinopathy Study charts, but no clinically significant changes for the other measures of visual function. Conclusion: The present study shows the potential efficacy of topical dorzolamide for treating choroideremia patients with cystoid macular edema. RETINA 32: 826-833, 2012
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