Journal
RESUSCITATION
Volume 81, Issue 2, Pages 224-229Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.resuscitation.2009.11.024
Keywords
Neonates; 100% oxygen; Room air; Return of spontaneous circulation
Categories
Funding
- Young Investigator Award
- NIH [NS056146]
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Background: The return of spontaneous circulation (ROSC) is a primary goal of resuscitation. For neonatal resuscitation the International Liaison Committee on Resuscitation (ILCOR) recommends oxygen concentrations ranging from 21% to 100%. Aims and methods: This study (a) compared the efficacy of resuscitation with room air (RA) or 100% O-2 in achieving ROSC in 46 neonatal mice with circulatory collapse induced by lethal hypoxia-ischemia (HI) and (b) determined whether re-oxygenation with RA or 100% O-2 alters the extent of HI cerebral injury in mice with preserved systemic circulation (n = 31). We also compared changes in generation of reactive oxygen species (ROS) in cerebral mitochondria in response to re-oxygenation with RA or 100% O-2. Result: In HI-mice with collapsed circulation re-oxygenation with 100% O-2 versus RA resulted in significantly greater rate of ROSC. In HI-mice with preserved systemic circulation and regional (unilateral) cerebral ischemia the restoration of cerebral blood flow was significantly faster upon re-oxygenation with 100% O-2, than RA. However, no difference in the extent of brain injury was detected. Regardless of the mode of re-oxygenation, reperfusion in these mice was associated with markedly accelerated ROS production in brain mitochondria. Conclusion: In murine HI associated with circulatory collapse the resuscitation limited to re-oxygenation with 100% O-2 is superior to the use of RA in achievement of the ROSC. However, in Hi-mice with preserved systemic circulation hyperoxic re-oxygenation has no benefit over the normoxic brain recovery. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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