Journal
RESPIROLOGY
Volume 23, Issue 11, Pages 1006-1022Publisher
WILEY
DOI: 10.1111/resp.13398
Keywords
bacterial infection; bronchiectasis; eradication; Pseudomonas aeruginosa; pulmonary exacerbations
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Funding
- Queensland Health Research Fellowship
- NHMRC [633235]
- Medical Research Futures Fund grant [APP1152249]
- Novartis through the Innovative Medicines Initiative (IMI 1)
- National Institutes of Health Research (UK)
- Medical Research Council (UK)
- European Commission Innovative Medicines Initiative
- National Institute for Health Research (NIHR)
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Interest in bronchiectasis has increased over the past two decades, as shown by the establishment of disease-specific registries in several countries, the publication of management guidelines and a growing number of clinical trials to address evidence gaps for treatment decisions. This review considers the evidence for defining and treating pulmonary exacerbations, the approaches for eradication of newly identified airway pathogens and the methods to prevent exacerbations through long-term treatments from a pragmatic practice-based perspective. Areas for future studies are also explored.
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