Journal
RESPIROLOGY
Volume 14, Issue 5, Pages 746-752Publisher
WILEY
DOI: 10.1111/j.1440-1843.2009.01550.x
Keywords
antibiotic; chronic obstructive pulmonary disease; hydrogen sulfide; pneumonia
Categories
Funding
- Capital Medicine Development Research Fund [2005-3014]
- Program for New Century Excellent Talents in University [985-2-082-113]
- National Natural Science Foundation of China [30871127]
Ask authors/readers for more resources
Background and objective: Endogenous hydrogen sulfide (H2S) may be involved in the pathogenesis of systemic inflammation. It was investigated whether serum H2S levels differed among patients with community-acquired pneumonia, those with exacerbations of COPD or control subjects, and whether H2S may be used as a surrogate marker of the need for antibiotic treatment. Methods: Serum H2S levels were measured in 129 patients with pneumonia or COPD exacerbations and in 72 healthy control subjects. Results: The mean serum H2S concentration was 36% lower in patients with pneumonia (22.7 +/- 14.6 mu mol/L) than in control subjects (35.4 +/- 5.3 mu mol/L) (P < 0.01). Serum H2S concentration did not differ between patients with acute exacerbations of COPD (33.8 +/- 18.6 mu mol/L) and control subjects. Within the COPD group, patients with Anthonisen type 1 exacerbations had a lower serum H2S concentration (22.5 +/- 11.6 mu mol/L) than control subjects, and those with type 3 exacerbations had a higher serum H2S concentration (54.2 +/- 21.3 mu mol/L) than control subjects. There was no difference between patients with type 2 exacerbations (41.7 +/- 8.4 mu mol/L) and control subjects. In patients requiring antibiotics, serum H2S concentration was 41% lower than in those not requiring antibiotics. The area under the receiver operating characteristic curve for H2S as a surrogate marker of the need for antibiotics was 0.862 (95% confidence interval: 0.805-0.919, P < 0.01). Serum H2S levels were inversely correlated with serum CRP levels (r = -0.337, P < 0.01). Conclusions: Serum H2S levels may be used as a marker in lower respiratory tract infections. Further studies are required to validate the role of serum H2S levels in guiding antibiotic selection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available