Journal
RESPIRATORY RESEARCH
Volume 13, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1465-9921-13-26
Keywords
Asthma; Gene-environment interaction; Irritant exposure; Smoking; TRP channel
Categories
Funding
- INSERM
- French Agency for Environmental and Occupational Health Safety [AFSSET-APR-SE-2004]
- French National Agency for Research [ANR 05-SEST-020-02/05-9-97, ANR 06-CEBS, ANR 10-PRSP]
- Merck Sharp Dohme (MSD)
- European Commission
- Albacete - Fondo de Investigaciones Santarias [97/0035-01, 13 99/0034-01, 99/0034-02]
- Hospital Universitario de Albacete, Consejeria de Sanidad
- Antwerp - FWO
- Flanders Belgium [G.0402.00]
- University of Antwerp
- Flemish Health Ministry
- Barcelona - Fondo de Investigaciones Sanitarias [99/0034-02, 99/0034-01]
- Red Respira [RTIC 03/11 ISC IIF]
- Deutsche Forschungsgemeinschaft (DFG) [FR 1526/1-1, MA 711/4-1]
- Galdakao - Basque Health Department
- Gothenburg - Swedish Heart Lung Foundation
- Swedish Foundation for Health Care Sciences & Allergy Research
- Swedish Asthma & Allergy Foundation
- Swedish Cancer & Allergy Foundation
- Grenoble - Programme Hospitalier de Recherche Clinique-DRC de Grenoble [2610]
- Ministry of Health, Directionde la Recherche Clinique
- Ministere de l'Emploi et de la Solidarite
- Direction Generale de la Sante
- CHU de Grenoble
- Comite des Maladies Respiratoires de l'Isere
- Hamburg - GSF-National Research Centre for Environment Health
- Ipswich and Norwich - Asthma UK
- Huelva - Fondo de Investigaciones Sanitarias (FIS) [97/0035-01, 99/003401, 99/003402]
- Montpellier - Programme Hospitalier de Recherche Clinique-DRC de Grenoble [2610]
- Ministry of Health, Direction de la Recherche Clinique
- Aventis (France)
- Direction Regionale des Affaires Sanitaires et Sociales Languedoc-Roussillon
- Oviedo Fondo de Investigaciones Santarias (FIS) [97/0035-01, 99/0034-02, 99/0034-01]
- Paris - Ministere de l'Emploi et de la Solidarite
- UCBPharma (France)
- Glaxo France
- Programme Hospitalier de Recherche Clinique-DRC de Grenoble [2610]
- Ministry of Health
- Direction de la Recherche Clinique
- Tartu - Estonian Science Foundation
- Umea - Swedish Heart Lung Foundation
- Uppsala - Swedish Heart Lung Foundation
- GABRIEL
- European Community [01896, LSH-2004-1.2.5-1]
- Netherlands Organisation for Scientific Research (NWO)/French Ministry of foreign and European affairs
- CIBERESP
- ICREA Academia
- Spanish Ministry of Science and Innovation
- FEDER
- Plan E [SAF2009-09848]
- Generalitat de Catalunya [2009SGR-1369]
- ISCIII-RETIC [RD06/02]
- Marato TV3 [080430]
- European Academy of Allergology and Clinical Immunology-Global Allergy and Asthma European Network (EAACI-GA2LEN)
- Medical Research Council [G0801056B, G0901214] Funding Source: researchfish
- MRC [G0901214] Funding Source: UKRI
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Background: Transient receptor potential (TRP) vanilloid and ankyrin cation channels are activated by various noxious chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence of single nucleotide polymorphisms (SNPs) in TRP genes and irritant exposures on cough. Methods: Nocturnal, usual, and chronic cough, smoking, and job history were obtained by questionnaire in 844 asthmatic and 2046 non-asthmatic adults from the Epidemiological study on the Genetics and Environment of Asthma (EGEA) and the European Community Respiratory Health Survey (ECRHS). Occupational exposures to vapors, gases, dusts, and/or fumes were assessed by a job-exposure matrix. Fifty-eight tagging SNPs in TRPV1, TRPV4, and TRPA1 were tested under an additive model. Results: Statistically significant associations of 6 TRPV1 SNPs with cough symptoms were found in non-asthmatics after correction for multiple comparisons. Results were consistent across the eight countries examined. Haplotype-based association analysis confirmed the single SNP analyses for nocturnal cough (7-SNP haplotype: p-global = 4.8 x 10(-6)) and usual cough (9-SNP haplotype: p-global = 4.5 x 10(-6)). Cough symptoms were associated with exposure to irritants such as cigarette smoke and occupational exposures (p < 0.05). Four polymorphisms in TRPV1 further increased the risk of cough symptoms from irritant exposures in asthmatics and non-asthmatics (interaction p < 0.05). Conclusions: TRPV1 SNPs were associated with cough among subjects without asthma from two independent studies in eight European countries. TRPV1 SNPs may enhance susceptibility to cough in current smokers and in subjects with a history of workplace exposures.
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