Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 203, Issue -, Pages 45-50Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2014.08.008
Keywords
Lung mechanics; Arterial blood gases; Histology; Inflammation; Cytokines
Categories
Funding
- Brazilian Council for Scientific and Technological Development (CNPq) [471438/2012-0]
- Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation (FAPERJ) [E-26/110.180/2013]
- National Institute of Science and Technology of Drugs and Medicines (INCT-INOFAR)
- European Community Seventh Framework Programme (TARKINAID, FP7) [FP7-HEALTH-2011-single-stage, HEALTH.2011.1.4]
- Centers of Excellence Program (PRONEX-FAPERJ)
- Coordination for the Improvement of Higher Education Personnel (CAPES)
- Sao Paulo State Research Supporting Foundation (FAPESP)
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We evaluated whether the short-term use of dexmedetomidine and propofol may attenuate inflammatory response and improve lung morphofunction in experimental acute lung injury (ALI). Thirty-six Wistar rats were randomly divided into five groups. Control (C) and ALI animals received sterile saline solution and Escherichia coli lipopolysaccharide by intraperitoneal injection respectively. After 24 h, ALI animals were randomly treated with dexmedetomidine, propofol, or thiopental sodium for 1 h. Propofol reduced static lung elastance and resistive pressure and was associated with less alveolar collapse compared to thiopental sodium and dexmedetomidine. Dexmedetomidine improved oxygenation, but did not modify lung mechanics or histology. Propofol was associated with lower IL (interleukin)-6 and IL-1 1 beta expression, whereas dexmedetomidine led to reduced inducible nitric oxide (iNOS) and increased nuclear factor erythroid 2-related factor 2 (Nrf2) expression in lung tissue compared to thiopental sodium. In conclusion, in this model of mild ALI, short-term use of dexmedetomidine and propofol led to different functional effects and activation of biological markers associated with pulmonary inflammation. (C) 2014 Elsevier B.V. All rights reserved.
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