Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 189, Issue 2, Pages 354-363Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2013.04.020
Keywords
Exercise hyperpnea; High altitude; Sleep apnea; Loop gain; Cheyne-Stokes; Oxygen induced hypercapnia; Lung
Categories
Funding
- AHA [0840159N]
- NIH [R01 HL090897, K24 HL 093218, 1 P01 HL 095491, R01HL110350, UM1HL108724, R01- AG035117, R01 HL085188]
- [UL1 RR 025758-01]
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Control of ventilation dictates various breathing patterns. The respiratory control system consists of a central pattern generator and several feedback mechanisms that act to maintain ventilation at optimal levels. The concept of loop gain has been employed to describe its stability and variability. Synthesizing all interactions under a general model that could account for every behavior has been challenging. Recent insight into the importance of these feedback systems may unveil therapeutic strategies for common ventilatory disturbances. In this review we will address the major mechanisms that have been proposed as mediators of some of the breathing patterns in health and disease that have raised controversies and discussion on ventilatory control over the years. (C) 2013 Elsevier B.V. All rights reserved.
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