Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 185, Issue 1, Pages 9-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2012.06.012
Keywords
Carotid body; Development; Maturation; Neurotransmitters; Trophic factors; Human
Categories
Ask authors/readers for more resources
Functional maturation of the carotid body in the postnatal period relies partly on structural and neurochemical changes, which are reviewed here. Structural changes include changes in cytological composition, and increases in glomic tissue volume, dense-cored granules of type I cells, synapses of type I cells with type II cells and afferent nerve fibres. Vascular volume also increases, but in the same proportion as extravascular volume. During maturation, the carotid body also shows higher density and hypoxic sensitivity of K+-channels and an increased hypoxic [Ca2+](i) response. Modulation of content and release of catecholamine occurs, together with decreased expression of tyrosine hydroxylase and dopamine beta-hydroxylase and increased expression of choline acetyltransferase. Expression of dopamine 2 receptor and nicotinic alpha 3 and alpha 7 receptor subunits increases, and muscarinic M1 receptor protein, nicotinic alpha 4 and beta 2 receptor subunits and adenosine receptor 1 decrease. Maturation of the carotid body may also be explained with reference to the developmentally regulated expression of trophic factors and their receptors. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available