4.2 Article

3,5,4′-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1α

Journal

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 185, Issue 3, Pages 608-614

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2012.11.016

Keywords

NF-kappa B; HIF-1 alpha; Lung injury; 3,5,4 '-Tri-O-acetylresveratrol

Funding

  1. G&k gold surface project: the mechanism of hypoxia-inducible factor 1alpha (HIF-1alpha) in seawater drowning-induced acute lung injury (SWD-ALI) [81270124]

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Resveratrol is a phytoalexin synthesized by a wide variety of plants, which has been proven to be effective in suppressing oxidative stress and inflammation. The aim of the present study was to investigate the effect of Resveratrol's prodrug: 3,5,4'-tri-O-acetylresveratrol, on seawater drowning-induced acute lung injury (SWD-ALI). Histological changes were assessed to study lung injuries; cytokines in lung samples were monitored by ELISA to reflect inflammation; T-SOD and MDA activity were detected to examine oxidative stress in lung tissues. Besides, we also tested the expression of NF-kappa B and HIF-1 alpha to probe the possible protecting mechanism of 3,5,4'-tri-O-acetylresveratrol on AWD-ALL The results showed that pretreatment with different doses of 3,5,4'-tri-O-acetylresveratrol improved seawater-induced lung histopathologic changes, alleviated lung edema, reduced the production of inflammatory mediators including TNF-alpha and IL-1 beta, inhibited MDA activity, and enhanced T-SOD activity, which was possibly associated with inhibition of NF-kappa B and HIF-1 alpha. In conclusion, the current study demonstrated that 3,5,4'-tri-O-acetylresveratrol exhibited a protective effect on SWD-ALI by inhibiting of the inflammatory response, which may also involve the suppression of oxidative stress in lung tissues. (C) 2012 Elsevier B.V. All rights reserved.

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