Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 180, Issue 2-3, Pages 298-304Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2011.12.009
Keywords
Homocysteine; Obstructive sleep apnea; Metabolic syndrome; Oxidative stress; Plasma thiols; Urinary 15-F-2t-isoprostane; Carotid intima-media thickness
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Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) are associated with increased cardiovascular morbidity and mortality. Increased homocysteine is suggested as an independent risk factor for atherosclerosis and cardiovascular disease but remains disputed in OSA. We assessed polysomnography, carotid intima-media thickness (CIMT) and biology in 35 MetS patients, according to the presence (OSA + mets: n = 26) or the absence of OSA (mets: is = 9). In OSA + MetS patients, homocysteine levels were increased compared to MetS subjects (12.8 +/- 3.8 vs. 9.5 +/- 2.5 mu mol/L; P = 0.026). In the whole population, homocysteine correlated with apnea-hypopnea index (AHI) (r = 0.522: P = 0.001) and CIMT (r = 0.376; P = 0.026). Homocysteine was negatively correlated with plasma thiols (r = -0.406; P = 0.017) and positively with urinary 15-F2t-isoprostanes (r = 0.347; P = 0.044). Multivariate regression analysis revealed that AHI (beta = 0.559; P < 0.001) and urinary 15-F2t-isoprostane (beta = 0.310; P = 0.018) were independently associated with homocysteine level. We conclude that homocysteine level was higher in MetS when associated with OSA and proportional to OSA severity. In this context, vascular remodeling appeared more severe and mediated by oxidative stress. (C) 2011 Elsevier B.V. All rights reserved.
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