Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 173, Issue -, Pages S37-S42Publisher
ELSEVIER
DOI: 10.1016/j.resp.2010.01.007
Keywords
Evolution of the blood-gas barrier, structure and function of the blood-gas barrier; Constraints on the blood-gas barrier; The surfactant system and evolution of the blood-gas barrier; Leptin and the evolution of the blood-gas barrier; Leptin signaling, the epidermal growth factor pathway, and formation and homeostatic regulation of the blood-gas barrier; Evolution of the blood-gas barrier in diving mammals
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Funding
- NCRR NIH HHS [M01 RR000827] Funding Source: Medline
- NHLBI NIH HHS [R01 HL081823, R01 HL037930, R01 HL085648, P01 HL017731, R01 HL055268] Funding Source: Medline
- Natural Environment Research Council [smru10001] Funding Source: researchfish
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The following are the proceedings of a symposium held at the Second International Congress for Respiratory Science in Bad Honnef, Germany The goals of the symposium were to delineate the blood-gas barrier phenotype across vertebrate species, to delineate the interrelationship between the evolution of the blood-gas barrier, locomotion and metabolism: to introduce the selection pressures for the evolution of the surfactant system as a key to understanding the physiology of the blood-gas barrier, to introduce the lung lipofibroblast and its product. leptin, which coordinately regulates pulmonary surfactant, type IV collagen in the basement membrane and host defense, as the cell-molecular site of selection pressure for the blood-gas barrier, to drill down to the gene regulatory network(s) involved in leptin signaling and the blood-gas barrier phenotype, to extend the relationship between leptin and the blood-gas barrier to diving mammals. (C) 2010 Elsevier B.V All rights reserved
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