Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 172, Issue 3, Pages 210-212Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2010.05.020
Keywords
Obstructive sleep apnea; Animal model; Airway obstruction; Inflammation
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Funding
- Ministerio de Ciencia y Tecnologia [SAF2008-02991, PI08/0277]
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The aim was to test the hypothesis that mesenchymal stem cells (MSC) could reduce the inflammation induced by recurrent airway occlusions in an animal model of obstructive sleep apnea (OSA). A nasal mask was applied to 30 anesthetized rats. Twenty rats were subjected to a pattern of recurrent obstructive apneas mimicking OSA (60/h, lasting 15 s each) for 5 h. MSC (5 x 10(6) cells) were intravenously injected into 10 of these rats. Ten rats not subjected to apneas or MSC injection were used as controls. The rat blood serum concentrations of pro-inflammatory cytokine IL-1 beta were measured by ELISA. IL-1 beta was significantly greater in the rats subjected to recurrent apneas (66.7 +/- 41.2 pg/mL; m +/- SEM) than in controls (1.9 +/- 1.0 pg/mL; p < 0.05). In the group of apneic rats subjected to MSC injection, IL-1 beta was significantly reduced (6.1 +/- 3.8 pg/mL; p < 0.05). In conclusion, MSC triggered an early anti-inflammatory response in rats subjected to recurrent obstructive apneas, suggesting that these stem cells could play a role in the physiological response to counterbalance inflammation in USA. (C) 2010 Elsevier B.V. All rights reserved.
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