Journal
RESPIRATORY MEDICINE
Volume 104, Issue 6, Pages 858-864Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2009.12.006
Keywords
CARDIA; Forced expiratory volume in 1 s (FEV1); Forced vital capacity (FVC); Forced expiratory time; Pulmonary function testing; Spirometry
Funding
- National Heart, Lung, and Blood Institute [N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050]
- National Heart, Lung, and Blood Institute CARDIA field centers [N01-HC-95095]
- National Heart, Lung, and Blood Institute CARDIA Coordinating Center [N01-HC045134]
- National Heart, Lung, and Blood Institute CARDIA Pulmonary Reading Center
- DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS [N01HC045134, N01HC048049] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL048049, R29HL048048, R01HL048050, R01HL048048] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Rationale: End of test criteria can influence spirometry results. Epidemiology studies initiated before adoption of the 1987 American Thoracic Society (ATS) guidelines typically used a 1 or 2s plateau on the volume-time curve, not a minimum test duration of 6 s, to terminate a test. Objectives: To determine the effect of changing guidelines on FEV1, FVC and FEV1/FVC during a longitudinal study of young adults. Methods: Spirometry was performed on participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Values obtained at entry and 2, 5 and 10 years later using accepted procedures were re-evaluated using the 2005 ATS ERS guidelines, which were in effect for the year 20 exam. Generalized estimating equations were used to adjust tests with short exhalations that were acceptable by then current end of test criteria. Results: The percentage of participants at years 0, 2, 5, and 10 with exhalations less than 6 s but with an acceptable plateau was 33%, 29%, 9%, and 2%, respectively. Exhalations less than 6 s occurred more frequently in younger and female participants, and were associated with lower FVC and higher FEV1/FVC. For short exhalations the adjusted FVC was 47 ml and 110 ml higher than the measured FVC when 6 and 8 s exhalation times were used. Conclusions: In longitudinal studies of young adults, changing end of test criteria may affect lung function, especially among younger and female participants. Determining adjusted values for tests with short exhalations may better represent the lung health of participants. (C)) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available