Journal
RESPIRATION
Volume 85, Issue 1, Pages 72-84Publisher
KARGER
DOI: 10.1159/000340044
Keywords
Electronic nose; Chemical sensors; Volatile organic compounds; Breathomics; Airway inflammation; Asthma; Chronic obstructive pulmonary disease; Lung cancer
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Funding
- Ministero dell'Istruzione
- dell'Universita e della Ricerca
- PRIN
- Catholic University of the Sacred Heart
- Fondi di Ateneo
- UBIO-PRED Project, Innovative Medicines Initiative (IMI)
- National Institute for Health Research [NF-SI-0611-10148] Funding Source: researchfish
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Several volatile organic compounds have been identified in exhaled breath in healthy subjects and patients with respiratory diseases by gas chromatography/mass spectrometry. Identification of selective patterns of volatile organic compounds in exhaled breath could be used as a biomarker of inflammatory lung diseases. An electronic nose (e-nose) is an artificial sensor system that generally consists of an array of chemical sensors for detection of volatile organic compound profiles (breathprints) and an algorithm for pattern recognition. E-noses are handheld, portable devices that provide immediate results. E-noses discriminate between patients with respiratory disease, including asthma, COPD and lung cancer, and healthy control subjects, and also among patients with different respiratory diseases. E-nose breathprints are associated with airway inflammation activity. In combination with other 'omics' platforms, e-nose technology might contribute to the identification of new surrogate markers of pulmonary inflammation and subphenotypes of patients with respiratory diseases, provide a molecular basis to a personalized pharmacological treatment, and facilitate the development of new drugs. Copyright (C) 2012 S. Karger AG, Basel
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