Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 41, Issue 9, Pages 6271-6281Publisher
SPRINGER
DOI: 10.1007/s11164-014-1738-y
Keywords
1,3-Dibromo-5,5-dimethylhydantoin (DBH); Multicomponent reaction; Thioacetamide; Thioamidoalkyl naphthol; Solvent-free
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Funding
- Ilam University, Ilam, Iran
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An efficient and easy method for one-pot three-component synthesis of thioamidoalkyl and bis(thio)amidoalkyl naphthols by condensation of aromatic aldehydes, 2-naphthol, and acetamide or thioacetamide under thermal condition at 130 degrees C in the presence of 1,3-dibromo-5,5-dimethylhydantoin is described. The present approach offers several advantages such as reduced reaction time, higher yield, and economic availability of the catalyst.
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