Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 41, Issue 6, Pages 3335-3347Publisher
SPRINGER
DOI: 10.1007/s11164-013-1436-1
Keywords
Click chemistry; Multi-component reaction; 1,2,3-Triazole; Imidazole; Ionic liqiud
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Funding
- Research Council of Shahid Beheshti University
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A new and efficient approach for the synthesis of 2,4,5-triaryl-1H-imidazoles linked 1,4-disubstitued 1,2,3-triazoles have been developed by multicomponent condensation with Huisgen 1,3-dipolar cycloaddition. A mixture of aromatic propargylated aldehydes, different azides, benzil, and ammonium acetate were condensed in the presence of catalytic amounts of acidic ionic liquid, 1-methylimidazolium trifluoroacetate, ([Hmim]TFA), and Cu(OAc)(2)/sodium ascorbate to afford the corresponding products. The features of this procedure are operational simplicity, good yields of products, and solvent-free conditions.
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