Synthesis and antimicrobial evaluation of ferulic acid derivatives

A series of ferulic acid derivatives (1-38) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated in vitro for their antimicrobial activity against different Gram-positive and Gram-negative bacterial and fungal strains by the tube dilution method. Results of antimicrobial screening indicated that compound 1 was the most active antimicrobial agent (pMIC(am) = 1.83 mu M/ml).